This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
Aliases： TRKB; trk-B; GP145-TrkB
Entrez GeneID： 4915
Swissprot ： Q16620
WB Predicted band size： 92kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human NTRK2 (AA: 207-339) expressed in E. Coli.
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