This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Aliases： BXR; PAR; PRR; PXR; SAR; SXR; ONR1; PAR1; PAR2; PARq
Entrez GeneID ： 8856
Swissprot： O75469
WB Predicted band size： 49.8kDa
Host/Isotype： Mouse IgG2b
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human NR1I2 (AA: 1-142) expressed in E. Coli.
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