The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).

Aliases:    NER; UNR; LXRB; LXR-b; NER-I; RIP15    

Entrez GeneID:    7376    

Swissprot:    P55055    

WB Predicted band size:    51kDa    

Host/Isotype:    Mouse IgG2b    

Species Reactivity:    Human    

Immunogen :   Purified recombinant fragment of human NR1H2 (AA:1-200) expressed in E. Coli.    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000