NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity.
Aliases: NFkappaB p65; p65; NFKB3; RELA
Entrez GeneID: 5970
Swissprot : Q04206
WB Predicted band size: 65kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human,Mouse,Rat,Rabbit,Monkey
Immunogen: Purified recombinant fragment of human NF-κB p65 expressed in E. Coli.
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