Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.Tissue specificity: Expressed in all tissues examined.

Aliases:    IKBB; TRIP9; NFKBIB    

Entrez GeneID:    4793    

Swissprot:    Q15653     

WB Predicted band size:    45kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human    

Immunogen :   Purified recombinant fragment of human NFKBIB expressed in E. Coli.    

WB    1/500 - 1/2000    

ELISA    1/10000