This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Aliases:    IKBA; MAD-3; NFKBI    

Entrez GeneID:    4792    

Swissprot :   P25963    

WB Predicted band size:    35.6kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of human NFKBIA (AA: 150-291) expressed in E. Coli.    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000