This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Aliases: p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100
Entrez GeneID: 4791
Swissprot: Q00653
WB Predicted band size: 96.7kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human,Mouse
Immunogen: Purified recombinant fragment of human NFKB2 (AA: 712-900) expressed in E. Coli.
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