Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.

Aliases:    NFH; CMT2CC    

Entrez GeneID:    4744    

Swissprot :   P12036    

WB Predicted band size :   112.4kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity :   Human    

Immunogen:    Purified recombinant fragment of human NEFH (AA: 2-251) expressed in E. Coli.    

IHC    1/200-1/1000    

ELISA    1/10000