NCOR1: Nuclear receptor co-repressor 1. This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.
Aliases: N-CoR; TRAC1; hN-CoR
Entrez GeneID: 9611
Swissprot: O75376
Host/Isotype: Mouse IgG1
Species Reactivity: Human
Immunogen : Purified recombinant fragment of NCOR1 (aa1-192) expressed in E. Coli.
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