This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue.
Aliases: MUC11; MUC-11;
Entrez GeneID: 10071
Swissprot: Q9UKN1
WB Predicted band size: 55.8kDa
Host/Isotype: Mouse IgG2b
Species Reactivity: Human
Immunogen: Purified recombinant fragment of human MUC12 (AA: extra 371-592) expressed in E. Coli.
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