This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Aliases ： ATLD; HNGS1; MRE11A; MRE11B
Entrez GeneID ： 4361
Swissprot ： P49959
WB Predicted band size： 80.6kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human, Rat
Immunogen ： Purified recombinant fragment of human MRE11 (AA: 182-582) expressed in E. Coli.
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