This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.

Aliases:    PERB11.2    

Entrez GeneID:    4277    

Swissprot:    Q29980    

WB Predicted band size:    42.6kDa    

Host/Isotype :   Mouse IgG1    

Species Reactivity:    Human    

Immunogen :   Purified recombinant fragment of human MICB (AA: extra 23-309) expressed in HEK293-6e cells supernatant.    

FCM    1/200 - 1/400    

ELISA    1/10000