This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1).

Aliases:    MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2    

Entrez GeneID:    57534    

Swissprot :   Q86YT6      

WB Predicted band size:    110kDa    

Host/Isotype :   Mouse IgG1    

Species Reactivity:    Human,Monkey    

Immunogen:    Purified recombinant fragment of human MIB1 (AA: 6-221) expressed in E. Coli.    

WB    1/500 - 1/2000    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000