MDM4, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2.

Aliases：    HDMX; MDMX; MRP1; MDM4    

Entrez GeneID：    4194    

Swissprot：   O15151    

WB Predicted band size：    55kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human MDM4 expressed in E. Coli.    

WB    1/500 - 1/2000   

IHC    1/200 - 1/1000    

IF/ICC    1/200 - 1/1000    

ELISA    1/10000