The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene.
Aliases： HCC5; P1.h; RLFB; P1-MCM3
Entrez GeneID： 4172
Swissprot ： P25205
WB Predicted band size ： 91kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human,Rat,Monkey
Immunogen： Purified recombinant fragment of human MCM3 expressed in E. Coli.
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