MATK (megakaryocyte-associated tyrosine kinase), also known as CTK, this protein has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
Aliases ： CHK; CTK
Entrez GeneID： 4145
Swissprot ： P42679
WB Predicted band size ： 56kDa
Host/Isotype ： Mouse IgG1
Species Reactivity ： Human
Immunogen： Purified recombinant fragment of human MATK expressed in E. Coli.
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