MAP2K2, also called MEK2, it is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.
Aliases： MEK2; MKK2; MAPKK2
Entrez GeneID： 5605
Swissprot ： P36507
WB Predicted band size ： 44kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Mouse,Rat
Immunogen ： Purified recombinant fragment of human MAP2K2 expressed in E. Coli.
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