LIM domain containing preferred translocation partner in lipoma. The Zyxin family of proteins contains five members, Ajuba, LIMD1, LPP,TRIP6 and Zyxin. LPP (LIM-containing lipoma-preferred partner), a LIM domain-containing scaffolding protein contains three LIM domains at its carboxy terminus, which are preceded by a proline-rich pre-LIM region containing a number of protein interaction domains. LPP, an 80 kDa protein, localizes to sites of cell adhesion, such as focal adhesions and cell-cell contacts,and shuttles to the nucleus where it has transcriptional activation capacity.The human LPP gene maps to chromosomal location 3q28, and preferentially translocates to the HMGIC gene in a subclass of human benign mesenchymal tumors known as lipomas.
Aliases ： LPP
Entrez GeneID： 4026
Swissprot： Q93052
WB Predicted band size： 66kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human,Mouse,Monkey,Hamster
Immunogen： Purified recombinant fragment of human LPP expressed in E. Coli.
WeChat
