This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy.

Aliases :   LMN2; LAMB2    

Entrez GeneID :   84823    

Swissprot :   Q03252     

WB Predicted band size:    67.7kDa    

Host/Isotype :   Mouse IgG2b    

Species Reactivity :   Human    

Immunogen:    Purified recombinant fragment of human LMNB2 (AA: 401-600) expressed in E. Coli.    

IHC    1/200 - 1/1000    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000