This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Aliases：    ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B    

Entrez GeneID ：   10859    

Swissprot :   Q8NHL6    

WB Predicted band size:    70.8kDa    

Host/Isotype :   Mouse IgG1    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of human LILRB1 (AA: extra 338-461) expressed in E. Coli.    

WB    1/500 - 1/2000    

ELISA    1/10000