Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.Tissue specificity: Highly expressed in testis and at lower levels in the submandibular salivary gland.

Aliases ：   DKIR; C3IP1; FLJ27152; KLHL12    

Entrez GeneID：    59349    

Swissprot ：   Q53G59     

WB Predicted band size ：   63kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：   Human    

Immunogen：    Purified recombinant fragment of human KLHL12 expressed in E. Coli.    

WB    1/500 - 1/2000    

ELISA    1/10000