This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.
Aliases: EKLF; INLU; HBFQTL6
Entrez GeneID: 10661
Swissprot : Q13351
WB Predicted band size: 38.2kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human
Immunogen: Purified recombinant fragment of human KLF1 (AA: 208-362) expressed in E. Coli.