This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Aliases：    INrf2; KLHL19    

Entrez GeneID：    9817    

Swissprot ：   Q14145    

WB Predicted band size ：   69.7kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity ：   Human,Mouse    

Immunogen ：   Purified recombinant fragment of human KEAP1 (AA: 380-624) expressed in E. Coli.    

WB    1/500 - 1/2000    

IF/ICC    1/50    

FCM    1/200 - 1/400    

ELISA    1/10000