Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

Aliases：    FLK1; CD309; VEGFR; VEGFR2    

Entrez GeneID ：   3791    

Swissprot：    P35968    

WB Predicted band size ：   151.5kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：   Human    

Immunogen ：   Purified recombinant fragment of human KDR (AA: 1225-1356) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000