JAK3, Janus kinase 3. It is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Aliases ： JAKL; LJAK
Entrez GeneID： 3718
Swissprot： P52333
WB Predicted band size： 125kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human,Mouse
Immunogen ： Purified recombinant fragment of human JAK3 expressed in E. Coli.
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