ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Aliases：    GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2    

Entrez GeneID：    3674    

Swissprot：    P08514        

WB Predicted band size ：   113.4kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. Coli.    

IHC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000