ISL1 (ISL1 transcription factor, LIM/homeodomain) is a member of the LIM/homeodomain family of transcription factors. It binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. It is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Mutations in this gene have been associated with maturity-onset diabetes of the young.
Aliases ： Isl-1; ISLET1
Entrez GeneID： 3670
Swissprot： P61371
WB Predicted band size ： 39kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human,Mouse,Rat,Rabbit
Immunogen： Purified recombinant fragment of human ISL1 expressed in E. Coli.
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