Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
Aliases： P59; ILK-2
Entrez GeneID ： 3611
Swissprot ： Q13418
WB Predicted band size ： 51.4kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Mouse,Monkey
Immunogen ： Purified recombinant fragment of human ILK (AA: 97-244) expressed in E. Coli.
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