The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Aliases： CD25; IL2R; TCGFR; IDDM10
Entrez GeneID ： 3559
Swissprot ： P01589
WB Predicted band size： 30.8kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Mouse,Monkey,Rat
Immunogen： Purified recombinant fragment of human IL2RA (AA: 34-139) expressed in E. Coli.
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