This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Aliases： T2D; FJHN; HNF2; LFB3; RCAD; TCF2; HPC11; LF-B3; MODY5; TCF-2; VHNF1; ADTKD3; HNF-1B; HNF1beta; HNF-1-beta
Entrez GeneID： 6928
Swissprot： P35680
WB Predicted band size： 61.3kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human, Mouse, Rat
Immunogen： Purified recombinant fragment of human HNF1B (AA: 23-132) expressed in E. Coli.
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