Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.

Aliases :   H4; H4/n; H4F2; H4FN; FO108; HIST2H4    

Entrez GeneID:    8370    

Swissprot:    P62805       

WB Predicted band size :   11.4kDa    

Host/Isotype :   Mouse IgG1    

Species Reactivity:    Human    

Immunogen:    Synthesized peptide of human HIST2H4A (AA: GGAKRHRK(Me3)VLRDNIQ) .    

ELISA    1/10000