Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.
Aliases : H4; H4/n; H4F2; H4FN; FO108; HIST2H4
Entrez GeneID: 8370
Swissprot : P62805
WB Predicted band size: 11.4kDa
Host/Isotype : Mouse IgG1
Species Reactivity: Human
Immunogen: Synthesized peptide of human HIST2H4A ( AA: GGAKRHRK(Me)VLRDNIQ ).
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