The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. 

Aliases :   HH; HFE1; HLA-H; MVCD7; TFQTL2; MGC103790; dJ221C16.10.1    

Entrez GeneID:    3077    

Swissprot:    Q30201       

WB Predicted band size :   40kDa    

Host/Isotype :   Mouse IgG1    

Species Reactivity:    Human    

Immunogen :   Purified recombinant fragment of human HFE expressed in E. Coli.    

IF/ICC    1/200 - 1/1000    

ELISA    1/10000