The C-erbB-2 (HER-2/neu) gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Amplification or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. High levels of c-erbB-2 were associated with estrogen receptor (ER) and progesterone receptor negativity. Overexpression of the c-erbB-2 oncogene has been shown to be associated with poor prognosis in ovarian and breast cance, The level of increased Neu expression can be a predictor of disease prognosis
Aliases: HER-2, C-erB-2, erbB-2
Entrez GeneID : 2064
Swissprot: P04626
Host/Isotype: Mouse IgG2b
Species Reactivity: Human
Immunogen : Purified recombinant fragment of HER-2 expressed in E. Coli.
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