Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.

Aliases ：   HD6; JM21; CPBHM; PPP1R90    

Entrez GeneID ：   10013    

Swissprot ：   Q9UBN7     

WB Predicted band size ：   131.4kDa    

Host/Isotype ：   Mouse IgG2b    

Species Reactivity：    Human    

Immunogen ：   Purified recombinant fragment of human HDAC6 (AA: 482-800) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000