Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Aliases ：   HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A    

Entrez GeneID ：   9759    

Swissprot：    P56524    

WB Predicted band size ：   119kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：    Human    

Immunogen ：   Purified recombinant fragment of human HDAC4 (AA: 456-592) expressed in E. Coli.    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000