This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.
Aliases ： TRYP2
Entrez GeneID ： 3003
Swissprot： P49863
WB Predicted band size ： 29kDa
Host/Isotype ： Mouse IgG2b
Species Reactivity ： Human
Immunogen ： Purified recombinant fragment of human GZMK (AA: 27-264) expressed in E. Coli.
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