This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.

Aliases：    mGlu5; GPRC1E; MGLUR5; PPP1R86    

Entrez GeneID：    2915    

Swissprot：   P41594      

WB Predicted band size ：   132.5kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human    

Immunogen ：   Purified recombinant fragment of human GRM5 (AA: extra 458-580) expressed in E. Coli.    

IHC    1/200 - 1/1000    

IF/ICC    1/200 - 1/1000    

ELISA    1/10000