The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. (provided by RefSeq)Tissue specificity: Expressed in peripheral blood leukocytes

Aliases：    GRK2; BARK1; FLJ16718; BETA-ARK1; ADRBK1    

Entrez GeneID ：   156    

Swissprot：    P25098    

WB Predicted band size ：   80kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity ：   Human,Mouse,Rat,Monkey    

Immunogen：    Purified recombinant fragment of human GRK2 expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

IF/ICC    1/200 - 1/1000    

ELISA    1/10000