This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.

Aliases：    HKPX2    

Entrez GeneID ：   2743    

Swissprot ：   P48167    

WB Predicted band size：    56.1kDa    

Host/Isotype ：   Mouse IgG2b    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human GLRB (AA: extra 23-160) expressed in E. Coli.    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000