This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Aliases：    TNFRSF18; AITR; CD357; GITR-D    

Entrez GeneID：    8784    

Swissprot ：   Q9Y5U5    

WB Predicted band size：    26kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：    Human    

Immunogen ：   Purified recombinant fragment of human GITR (AA: 184-241) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000