Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis. It catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Besides its functioning as a glycolytic enzyme in cytoplasm, recent evidence suggest that mammalian GAPDH is also involved in a great number of intracellular proceses such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication, and DNA repair. During the last decade a lot of findings appeared concerning the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age- related neuronal diseases, such as Alzheimer
Aliases： G3PD; GAPD; MGC88685;Glyceraldehyde-3-phosphate dehydrogenase
Entrez GeneID ： 2597
Swissprot ： P04406
WB Predicted band size： 37kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human,Mouse,Rat,Rabbit,Monkey,Pig
Immunogen ： Purified recombinant fragment of human GAPDH expressed in E. Coli.
WeChat
