This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
Aliases： GAD65
Entrez GeneID： 2572
Swissprot ： Q05329
WB Predicted band size ： 65.4kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human
Immunogen ： Purified recombinant fragment of human GAD2 (AA: 1-100) expressed in E. Coli.
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