The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.

Aliases：    HG20; GPR51; GPRC3B; GABABR2; HRIHFB2099    

Entrez GeneID：    9568    

Swissprot：    O75899    

WB Predicted band size：    105.8kDa    

Host/Isotype：    Mouse IgG2a    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human GABBR2 (AA: 319-483) expressed in E. Coli.    

IHC    1/200 - 1/1000    

ELISA    1/10000