This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Entrez GeneID： 9846
Swissprot： Q9UQC2
WB Predicted band size： 74.5kDa
Host/Isotype： Mouse IgG2a
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human GAB2 (AA: 332-476) expressed in E. Coli.
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