FGR: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as SRC2; c-fgr; c-src2; FLJ43153; MGC75096; p55c-fgr; p58c-fgr. It is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Aliases： SRC2; c-fgr; c-src2; p55c-fgr; p58c-fgr
Entrez GeneID ： 2268
Swissprot ： P09769
WB Predicted band size： 56kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human,Mouse
Immunogen ： Purified recombinant fragment of human FGR expressed in E. Coli.
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