The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.

Aliases:    IRE1; IRE1P; IRE1a; hIRE1p; FLJ30999; MGC163277; MGC163279; ERN1    

Entrez GeneID:    2081    

Swissprot:    O75460    

WB Predicted band size:    109kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity :   Human    

Immunogen:    Purified recombinant fragment of human ERN1(aa282-433) expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

ELISA    1/10000