eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk.
Aliases： CBP; EIF4F; EIF4E1; EIF4EL1; MGC111573; EIF4E
Entrez GeneID： 1977
Swissprot ： P06730
WB Predicted band size： 25kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human EIF4E expressed in E. Coli.
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