This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.

Aliases：    ET1; QME; PPET1; ARCND3; HDLCQ7    

Entrez GeneID：    1906    

Swissprot：    P05305     

WB Predicted band size：    24.4KDa    

Host/Isotype ：   Mouse IgG2a    

Species Reactivity ：   Human, Mouse    

Immunogen：    Purified recombinant fragment of human EDN1 (AA: 18-212) expressed in E. Coli.    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000