This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Aliases：    DAB2; DOC-2    

Entrez GeneID ：   1601    

Swissprot：    P98082    

WB Predicted band size ：   82.4kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human    

Immunogen ：   Purified recombinant fragment of human DOC2 (AA: 652-749) expressed in E. Coli.    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000